Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)

This program funds research that reuses existing data to study substance use, substance use disorder, and related HIV outcomes, including analyses of behavioral, health services, neuroimaging, social science, and other public or restricted datasets. Eligible applicants include a wide range of U.S. and non-U.S. organizations, including nonprofits, universities, governments, for-profits, small businesses, and foreign organizations. NIDA plans to commit $2 million in FY 2026 for two to four awards, plus an additional $2 million for two to four awards focused on HIV research under this announcement and a companion RFA. The combined direct cost budget for the two-year project period may not exceed $275,000, with no more than $200,000 requested in any single year, and no cost sharing is required. Clinical trials and applications involving new primary data collection are not allowed, and foreign components are permitted.

✳ AI-generated summary — verify against the announcement

• Education
• Health
• Research & Discovery
• Researchers & Scholars
• Biomedical & Disease Research
• Health Care Delivery, Access & Workforce
• Substance Use & Addiction

• ✓ City or township governments
• ✓ County governments
• ✓ For-profit organizations other than small businesses
• ✓ Independent school districts
• ✓ Native American tribal governments (Federally recognized)
• ✓ Native American tribal organizations (other than Federally recognized)
• ✓ Nonprofits with 501(c)(3) status (other than higher education)
• ✓ Nonprofits without 501(c)(3) status (other than higher education)
• ✓ Others
• ✓ Private institutions of higher education
• ✓ Public and State controlled institutions of higher education
• ✓ Public housing authorities / Indian housing authorities
• ✓ Small businesses
• ✓ Special district governments
• ✓ State governments