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Simpler Grants

No. PAR-24-304 · National Institutes of Health

Open

Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01 Clinical Trial Not Allowed)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement
Award range
Not specified
Expected awards
Not specified
Application deadline
Oct 14, 2026
Posted
Oct 10, 2024
Last verified
5 days ago

At a glance

AI summary

This program funds revision applications from currently funded NCI R01 projects to adapt and clinically validate existing biomarkers or assays for cancer detection, diagnosis, prognosis, monitoring, prediction of treatment response, prevention, or control. It does not fund early technology development or clinical trials, and applications must not propose clinical trials. Eligible applicants include many U.S. and foreign organizations, including nonprofits, universities, governments, for-profits, small businesses, and foreign organizations. The application budget is limited to $150,000 in direct costs in any single year, the maximum project period is 3 years, and the parent R01 must have at least two years of support remaining at the estimated time of award. No cost sharing is required.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Health
  • Research & Discovery
  • Researchers & Scholars
  • Biomedical & Disease Research
Official description from grants.gov

Through this Notice of Funding Opportunity (NOFO) is to accelerate the pace of translation of NCI-supported methods/assays/technologies (referred to as "assays") to the clinic. Specifically, the focus of this NOFO is on the adaption and clinical validation of molecular/cellular/imaging markers (referred to as "markers" r "biomarkers") for cancer detection, diagnosis, prognosis, monitoring, and prediction of response in treatment, as well as markers for cancer control and prevention. Research applications may support the acquisition of well-annotated specimens from NCI-supported or other clinical trials or observational cohorts/consortia for the purpose of clinical validation of the assay. Research projects proposed for this NOFO encourage multi-disciplinary interaction among scientific investigators, assay developers, clinicians, statisticians, and clinical laboratory staff. Clinical laboratory scientist(s) and statistical experts are highly encouraged to comprise integral parts of the application. This NOFO is not intended to support early-stage development of technology or the conduct of clinical trials, but rather the adaption and validation of assays to the point where they could be integrated into clinical trials as investigational assays/tools/devices.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide

Program history

USASpending.gov

Assistance listing 93.394 · Cancer Detection and Diagnosis Research

Real awards this federal program has made — the whole assistance listing (93.394), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 137 $595,012 $414,585 – $662,610
FY 2025 184 $726,875 $399,923 – $1,297,708
FY 2024 215 $1,129,641 $414,953 – $1,862,878
FY 2023 268 $1,754,736 $438,924 – $2,398,100
FY 2022 277 $2,036,627 $596,368 – $3,077,027
FY 2021 269

Dollar figures are based on the 1,000 most recent awards we store, not all 1,350 — award counts are complete.

Who wins it Higher education (836), Nonprofit (284), Business (196) of 1,350 awards — categories can overlap.
Top states CA (184) · NY (79) · MA (78) · TX (66) · PA (26)
Largest recent awards
  1. TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE $8,347,015 · FY 2022
  2. BATTELLE MEMORIAL INSTITUTE $6,630,183 · FY 2022
  3. THE JOHNS HOPKINS UNIVERSITY $6,618,085 · FY 2022
  4. SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $6,181,895 · FY 2022
  5. OREGON HEALTH & SCIENCE UNIVERSITY $5,771,926 · FY 2022

Source: USASpending.gov · refreshed Aug 14, 2026