Catalyze: Product Definition Medical Device Prototype Optimization (R33 - Clinical Trial Not Allowed)

This program funds early-stage product development for medical devices, diagnostics, and research tools related to HLBS diseases and disorders, including prototype testing or design changes, assay development, and product improvement. Only applications that do not propose clinical trials are allowed. Eligible applicants include many U.S. organizations such as nonprofits, universities, governments, for-profits, small businesses, and tribal entities, but foreign organizations are not eligible; foreign components of U.S. organizations are allowed. Awards are limited to direct costs of up to $300,000 per year, for a maximum project period of two years, and NHLBI expects up to 24 new awards across FY 2026 through FY 2028 under this notice and three companion announcements. Cost matching is expected, with at least a 0.25:1 non-federal cash match of the federal direct costs requested, and at least one Accelerator Partner with a support letter is required.

✳ AI-generated summary — verify against the announcement

• Health
• Technology & Product Development
• Training, Fellowship & Career Development
• Researchers & Scholars
• Biomedical & Disease Research

• ✓ City or township governments
• ✓ County governments
• ✓ For-profit organizations other than small businesses
• ✓ Independent school districts
• ✓ Native American tribal governments (Federally recognized)
• ✓ Native American tribal organizations (other than Federally recognized)
• ✓ Nonprofits with 501(c)(3) status (other than higher education)
• ✓ Nonprofits without 501(c)(3) status (other than higher education)
• ✓ Others
• ✓ Private institutions of higher education
• ✓ Public and State controlled institutions of higher education
• ✓ Public housing authorities / Indian housing authorities
• ✓ Small businesses
• ✓ Special district governments
• ✓ State governments