No. PAR-25-182 · National Institutes of Health
Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required)
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement
- Award range
- Not specified
- Expected awards
- Not specified
- Application deadline
- Oct 15, 2027
- Posted
- Nov 26, 2024
- Last verified
- Yesterday
At a glance
AI summaryThis program funds early-stage psychosocial intervention development and testing for mental disorders in adults and children, using a phased R61/R33 clinical trial approach. Applicants must propose a novel target, mechanism, or intervention strategy, and the study must measure whether the intervention changes that target or mechanism. The R61 phase supports up to 2 years, with the possibility of up to 3 additional years in the R33 phase if R61 milestones are met. The announcement does not state a cost-share requirement, and it limits work on novel pharmacologic interventions, neuromodulatory devices, broad societal exposures like poverty or violence, nonhuman animal studies, and simple translation of existing interventions to technology platforms.
AI-generated summary — verify against the announcement
What it funds
Official description from grants.gov
Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33 Clinical Trial Required). As part of NIMH's clinical trials pipeline, this NOFO encourages pilot research developing and testing novel psychosocial interventions and/or targets. Consistent with NIMH's emphasis on the experimental therapeutics approach to intervention development, it intends to speed the translation of emergent research in basic, behavioral, cognitive, affect, and neuropsychological science into preventative or therapeutic interventions. This RFA will provide up to two years of support for evaluation of target engagement and establishment of intervention parameters, and up to three years of support to replicate target engagement from prior studies and to test the association between target engagement and change in clinical outcome(s).
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments
Program history
USASpending.govAssistance listing 93.242 · Mental Health Research Grants
Real awards this federal program has made — the whole assistance listing (93.242), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 491 | $451,000 | $167,702 – $811,948 |
| FY 2025 | 600 | $731,738 | $320,544 – $1,460,736 |
| FY 2024 | 883 | — | — |
| FY 2023 | 898 | — | — |
| FY 2022 | 986 | — | — |
| FY 2021 | 945 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 4,803 — award counts are complete.
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY $21,714,815 · FY 2025
- OHIO STATE UNIVERSITY, THE $19,515,757 · FY 2025
- ALBERT EINSTEIN COLLEGE OF MEDICINE $18,270,924 · FY 2025
- DUKE UNIVERSITY $15,039,330 · FY 2025
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI $12,007,972 · FY 2026
Source: USASpending.gov · refreshed Aug 6, 2026