Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 Clinical Trial Required)

This program funds pilot hybrid effectiveness-implementation trials of mental health interventions and related implementation strategies in routine care, community, school, or online settings. It supports work to optimize, personalize, augment, or sequence prevention or treatment approaches, and applicants must evaluate both clinical outcomes and at least one hypothesized mechanism of action. Eligible applicants include a wide range of U.S. and foreign organizations, including nonprofits, schools, governments, for-profits, and tribal organizations, and foreign components are allowed. NIMH intends to commit $27 million in FY 2026 for this NOFO and companion announcements, with direct costs limited to $750,000 over up to three years and no more than $250,000 in any single year. No cost sharing is required.

✳ AI-generated summary — verify against the announcement

• Health
• Research & Discovery
• Patients & People with Health Conditions
• Mental & Behavioral Health

• ✓ City or township governments
• ✓ County governments
• ✓ For-profit organizations other than small businesses
• ✓ Independent school districts
• ✓ Native American tribal governments (Federally recognized)
• ✓ Native American tribal organizations (other than Federally recognized)
• ✓ Nonprofits with 501(c)(3) status (other than higher education)
• ✓ Nonprofits without 501(c)(3) status (other than higher education)
• ✓ Others
• ✓ Private institutions of higher education
• ✓ Public and State controlled institutions of higher education
• ✓ Public housing authorities / Indian housing authorities
• ✓ Small businesses
• ✓ Special district governments
• ✓ State governments