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Simpler Grants

No. PAR-25-378 · National Institutes of Health

Open

Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)

grants.gov listing Full announcement (NOFO)
Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement
Award range
Not specified
Expected awards
Not specified
Application deadline
Jan 7, 2027
Posted
Jan 22, 2025
Last verified
Yesterday

At a glance

AI summary

This program funds planning and development studies for interventions to improve the health of Native populations, including pilot or feasibility research ahead of a future clinical trial. It is open to a wide range of U.S. organizations, including nonprofits, tribal governments, schools, governments, small businesses, and faith-based or community-based organizations; foreign organizations and non-U.S. components of U.S. organizations are not eligible. Applicants may request up to $450,000 in direct costs over three years, with no more than $225,000 in direct costs in any single year. No cost sharing is required. The announcement does not list a geographic restriction, but projects must be community-engaged and focused on Native populations, including American Indian, Alaska Native, Urban Indian, and Native Hawaiian communities as defined in the notice.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Environment
  • Health
  • Income Security and Social Services
  • Research & Discovery
  • Tribal & Indigenous Communities
  • Biomedical & Disease Research
  • Health Care Delivery, Access & Workforce
  • Public Health, Prevention & Nutrition
Official description from grants.gov

The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native American (NA) populations. This includes 1) etiologic research, where there is a significant gap in knowledge, that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests the efficacy or effectiveness of health promotion and disease prevention interventions, 3) research that tests culturally informed treatment or recovery interventions and 4) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. For the purposes of this NOFO, NA includes the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. main land).

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide

Program history

USASpending.gov

Assistance listing 93.113 · Environmental Health

Real awards this federal program has made — the whole assistance listing (93.113), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 149 $379,262 $119,524 – $644,459
FY 2025 210 $431,750 $254,376 – $1,187,118
FY 2024 281 $583,878 $300,000 – $1,672,899
FY 2023 242 $587,197 $216,320 – $1,842,227
FY 2022 258 $465,538 $259,613 – $2,117,638
FY 2021 239 — —

Dollar figures are based on the 1,000 most recent awards we store, not all 1,379 — award counts are complete.

Who wins it Higher education (1,027), Nonprofit (157), Business (146) of 1,379 awards — categories can overlap.
Top states CA (132) · NY (120) · MA (87) · NC (66) · TX (40)
Largest recent awards
  1. VANDERBILT UNIVERSITY MEDICAL CENTER $32,769,976 · FY 2023
  2. NORTH CAROLINA STATE UNIVERSITY $10,038,112 · FY 2023
  3. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $9,460,610 · FY 2022
  4. THE JOHNS HOPKINS UNIVERSITY $9,120,320 · FY 2022
  5. TRUSTEES OF BOSTON UNIVERSITY $8,944,898 · FY 2023

Source: USASpending.gov · refreshed Aug 16, 2026

Assistance listing 93.121 · Oral Diseases and Disorders Research

Real awards this federal program has made — the whole assistance listing (93.121), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 155 $429,000 $306,500 – $571,863
FY 2025 277 $429,000 $310,295 – $829,259
FY 2024 301 $491,193 $310,985 – $1,283,003
FY 2023 320 $444,000 $298,673 – $1,756,575
FY 2022 295 — —
FY 2021 305 — —

Dollar figures are based on the 1,000 most recent awards we store, not all 1,653 — award counts are complete.

Who wins it Higher education (1,224), Nonprofit (242), Business (71) of 1,653 awards — categories can overlap.
Top states CA (124) · PA (83) · MA (82) · NY (70) · TX (35)
Largest recent awards
  1. TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE $6,128,166 · FY 2023
  2. THE GENERAL HOSPITAL CORPORATION $4,961,133 · FY 2023
  3. RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK $4,002,156 · FY 2023
  4. DANA-FARBER CANCER INSTITUTE, INC. $3,742,682 · FY 2025
  5. TRUSTEES OF INDIANA UNIVERSITY $3,736,064 · FY 2023

Source: USASpending.gov · refreshed Aug 16, 2026

Assistance listing 93.213 · Research and Training in Complementary and Integrative Health

Real awards this federal program has made — the whole assistance listing (93.213), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 58 $441,813 $190,230 – $676,906
FY 2025 51 $472,500 $321,065 – $1,329,943
FY 2024 100 $562,397 $286,558 – $1,285,052
FY 2023 92 $695,557 $380,313 – $1,709,004
FY 2022 94 $715,153 $419,983 – $1,985,928
FY 2021 92 $1,686,420 $625,217 – $3,082,386
Who wins it Higher education (342), Nonprofit (97), Business (33) of 487 awards — categories can overlap.
Top states CA (77) · MA (59) · NY (29) · NC (12) · IL (11)
Largest recent awards
  1. REGENTS OF THE UNIVERSITY OF MINNESOTA $21,646,919 · FY 2022
  2. UNIVERSITY OF FLORIDA $11,192,369 · FY 2022
  3. DUKE UNIVERSITY $7,025,837 · FY 2022
  4. THE RAND CORPORATION $6,237,409 · FY 2023
  5. THE SPAULDING REHABILITATION HOSPITAL CORPORATION $5,991,655 · FY 2023

Source: USASpending.gov · refreshed Aug 21, 2026

Assistance listing 93.242 · Mental Health Research Grants

Real awards this federal program has made — the whole assistance listing (93.242), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 491 $451,000 $167,702 – $811,948
FY 2025 600 $731,738 $320,544 – $1,460,736
FY 2024 883 — —
FY 2023 898 — —
FY 2022 986 — —
FY 2021 945 — —

Dollar figures are based on the 1,000 most recent awards we store, not all 4,803 — award counts are complete.

Who wins it Higher education (3,532), Nonprofit (816), Business (215) of 4,803 awards — categories can overlap.
Top states CA (166) · NY (127) · MA (104) · PA (79) · IL (22)
Largest recent awards
  1. MASSACHUSETTS INSTITUTE OF TECHNOLOGY $21,714,815 · FY 2025
  2. OHIO STATE UNIVERSITY, THE $19,515,757 · FY 2025
  3. ALBERT EINSTEIN COLLEGE OF MEDICINE $18,270,924 · FY 2025
  4. DUKE UNIVERSITY $15,039,330 · FY 2025
  5. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI $12,007,972 · FY 2026

Source: USASpending.gov · refreshed Aug 6, 2026

Assistance listing 93.273 · Alcohol Research Programs

Real awards this federal program has made — the whole assistance listing (93.273), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 100 $308,491 $157,932 – $601,291
FY 2025 175 $440,566 $194,934 – $1,114,948
FY 2024 237 $420,927 $153,632 – $1,110,810
FY 2023 327 $619,032 $350,328 – $1,806,361
FY 2022 314 $897,120 $369,477 – $2,547,224
FY 2021 274 — —

Dollar figures are based on the 1,000 most recent awards we store, not all 1,427 — award counts are complete.

Who wins it Higher education (1,103), Nonprofit (187), Business (75) of 1,427 awards — categories can overlap.
Top states CA (118) · NC (58) · NY (57) · PA (41) · TX (40)
Largest recent awards
  1. THE JOHNS HOPKINS UNIVERSITY $36,249,682 · FY 2022
  2. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $9,079,530 · FY 2022
  3. BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA $6,335,676 · FY 2023
  4. VANDERBILT UNIVERSITY $5,361,769 · FY 2024
  5. LOHOCLA RESEARCH CORP $5,128,513 · FY 2022

Source: USASpending.gov · refreshed Aug 6, 2026

Assistance listing 93.279 · Drug Use and Addiction Research Programs

Real awards this federal program has made — the whole assistance listing (93.279), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 428 $422,523 $183,034 – $700,682
FY 2025 588 $709,054 $348,214 – $1,489,059
FY 2024 714 — —
FY 2023 724 — —
FY 2022 740 — —
FY 2021 606 — —

Dollar figures are based on the 1,000 most recent awards we store, not all 3,800 — award counts are complete.

Who wins it Higher education (2,743), Nonprofit (534), Business (366) of 3,800 awards — categories can overlap.
Top states CA (130) · MA (90) · NY (86) · PA (72) · MD (56)
Largest recent awards
  1. FLORIDA INTERNATIONAL UNIVERSITY $7,372,834 · FY 2025
  2. BETH ISRAEL DEACONESS MEDICAL CENTER, INC. $7,081,684 · FY 2025
  3. UNIVERSITY OF WASHINGTON $7,003,822 · FY 2025
  4. REACX PHARMACEUTICALS, INC. $6,900,000 · FY 2025
  5. WORCESTER POLYTECHNIC INSTITUTE $6,889,914 · FY 2025

Source: USASpending.gov · refreshed Aug 18, 2026

Assistance listing 93.310 · Trans-NIH Research Support

Real awards this federal program has made — the whole assistance listing (93.310), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 115 $582,838 $418,649 – $860,735
FY 2025 401 $786,876 $385,000 – $1,467,198
FY 2024 455 $1,174,898 $558,715 – $2,057,532
FY 2023 643 $1,437,358 $1,200,000 – $2,578,153
FY 2022 666 — —
FY 2021 689 — —

Dollar figures are based on the 1,000 most recent awards we store, not all 2,969 — award counts are complete.

Who wins it Higher education (2,212), Nonprofit (582), Business (34) of 2,969 awards — categories can overlap.
Top states CA (153) · MA (103) · NY (93) · PA (63) · MI (21)
Largest recent awards
  1. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $34,424,926 · FY 2023
  2. THE GENERAL HOSPITAL CORPORATION $33,014,143 · FY 2023
  3. MAYO CLINIC JACKSONVILLE (A NONPROFIT CORPORATION) $17,574,818 · FY 2024
  4. TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE $16,308,508 · FY 2025
  5. UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC. $14,064,599 · FY 2025

Source: USASpending.gov · refreshed Aug 18, 2026

Assistance listing 93.313 · NIH Office of Research on Women's Health

Real awards this federal program has made — the whole assistance listing (93.313), not just this notice.

No grants-family awards recorded for this program since FY 2021 — it may be new, renamed, or not yet reported to USASpending.

Source: USASpending.gov · refreshed Aug 30, 2026

Assistance listing 93.361 · Nursing Research

Real awards this federal program has made — the whole assistance listing (93.361), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 53 $732,795 $180,941 – $1,130,466
FY 2025 62 $675,031 $385,758 – $1,535,483
FY 2024 98 $473,202 $285,582 – $1,868,705
FY 2023 102 $758,157 $158,307 – $2,468,665
FY 2022 118 $493,973 $295,328 – $2,431,395
FY 2021 108 $478,145 $361,349 – $2,696,899
Who wins it Higher education (429), Nonprofit (54), Business (33) of 541 awards — categories can overlap.
Top states NY (48) · CA (35) · MD (32) · PA (31) · OH (25)
Largest recent awards
  1. UNIVERSITY OF CALIFORNIA, LOS ANGELES $13,344,757 · FY 2022
  2. THE REGENTS OF THE UNIVERSITY OF COLORADO $10,385,570 · FY 2025
  3. BAYLOR COLLEGE OF MEDICINE $8,282,292 · FY 2021
  4. THE LELAND STANFORD JUNIOR UNIVERSITY $6,476,031 · FY 2025
  5. UNIVERSITY OF MIAMI $4,547,851 · FY 2023

Source: USASpending.gov · refreshed Aug 30, 2026

Assistance listing 93.865 · Child Health and Human Development Extramural Research

Real awards this federal program has made — the whole assistance listing (93.865), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 386 $392,826 $79,188 – $593,582
FY 2025 665 $452,972 $178,000 – $1,225,547
FY 2024 785 — —
FY 2023 835 — —
FY 2022 799 — —
FY 2021 764 — —

Dollar figures are based on the 1,000 most recent awards we store, not all 4,234 — award counts are complete.

Who wins it Higher education (3,137), Nonprofit (693), Business (224) of 4,234 awards — categories can overlap.
Top states CA (103) · MA (87) · PA (75) · NY (62) · MI (34)
Largest recent awards
  1. PRESIDENT AND FELLOWS OF HARVARD COLLEGE $16,115,056 · FY 2025
  2. UNIVERSITY OF MIAMI $15,385,183 · FY 2025
  3. UNIVERSITY OF WASHINGTON $6,635,347 · FY 2025
  4. GEORGE WASHINGTON UNIVERSITY (THE) $5,117,920 · FY 2025
  5. RESEARCH TRIANGLE INSTITUTE $4,847,747 · FY 2025

Source: USASpending.gov · refreshed Aug 23, 2026

Assistance listing 93.866 · Aging Research

Real awards this federal program has made — the whole assistance listing (93.866), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 795 $493,972 $248,999 – $713,195
FY 2025 1,033 $643,089 $467,538 – $1,733,010
FY 2024 1,560 — —
FY 2023 1,539 — —
FY 2022 1,715 — —
FY 2021 1,595 — —

Dollar figures are based on the 1,000 most recent awards we store, not all 8,237 — award counts are complete.

Who wins it Higher education (6,015), Nonprofit (1,370), Business (538) of 8,237 awards — categories can overlap.
Top states CA (153) · NY (110) · MA (100) · TX (57) · PA (41)
Largest recent awards
  1. REGENTS OF THE UNIVERSITY OF MICHIGAN $15,345,206 · FY 2026
  2. UNIVERSITY OF UTAH $10,793,501 · FY 2025
  3. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $10,223,348 · FY 2026
  4. SUTTER BAY HOSPITALS $9,466,491 · FY 2025
  5. TUFTS MEDICAL CENTER PARENT, INC. $8,296,115 · FY 2026

Source: USASpending.gov · refreshed Aug 23, 2026