No. PAR-25-255 · National Institutes of Health
Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement
- Award range
- Not specified
- Expected awards
- Not specified
- Application deadline
- Nov 5, 2026
- Posted
- Nov 15, 2024
- Last verified
- Today
At a glance
AI summaryThis program funds new theory, models, and methods to better understand the genetic architecture of complex human traits, including work that integrates genetic and non-genetic factors across biological, social, and ecological scales. It is open to a wide range of applicants, including nonprofits, universities, governments, small businesses, for-profits, and foreign organizations, and foreign components of U.S. organizations are allowed. Awards are made as grants; the number of awards depends on NIH appropriations and meritorious applications, and budgets are not limited overall, though NCI applications are capped at $350,000 in direct costs per year. The project period may be up to 5 years, cost sharing is not required, and clinical trials are not allowed.
AI-generated summary — verify against the announcement
What it funds
Official description from grants.gov
The goal of this NOFO is to support applications for novel theory and methods development that enable better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary drawing from the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, modeling, and validation with available large-scale datasets.
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments
Program history
USASpending.govAssistance listing 93.172 · Human Genome Research
Real awards this federal program has made — the whole assistance listing (93.172), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 59 | $719,909 | $248,971 – $2,040,991 |
| FY 2025 | 100 | $491,802 | $283,764 – $1,360,276 |
| FY 2024 | 180 | $737,013 | $395,019 – $1,360,662 |
| FY 2023 | 179 | $766,801 | $392,035 – $2,341,997 |
| FY 2022 | 175 | $894,953 | $401,519 – $2,830,080 |
| FY 2021 | 215 | $1,999,233 | $431,511 – $5,047,468 |
- BAYLOR COLLEGE OF MEDICINE $26,395,336 · FY 2021
- UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $24,964,130 · FY 2021
- THE LELAND STANFORD JUNIOR UNIVERSITY $22,977,417 · FY 2021
- THE BROAD INSTITUTE, INC $22,339,977 · FY 2021
- JACKSON LABORATORY $21,311,202 · FY 2021
Source: USASpending.gov · refreshed Aug 16, 2026
Assistance listing 93.242 · Mental Health Research Grants
Real awards this federal program has made — the whole assistance listing (93.242), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 491 | $451,000 | $167,702 – $811,948 |
| FY 2025 | 600 | $731,738 | $320,544 – $1,460,736 |
| FY 2024 | 883 | — | — |
| FY 2023 | 898 | — | — |
| FY 2022 | 986 | — | — |
| FY 2021 | 945 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 4,803 — award counts are complete.
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY $21,714,815 · FY 2025
- OHIO STATE UNIVERSITY, THE $19,515,757 · FY 2025
- ALBERT EINSTEIN COLLEGE OF MEDICINE $18,270,924 · FY 2025
- DUKE UNIVERSITY $15,039,330 · FY 2025
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI $12,007,972 · FY 2026
Source: USASpending.gov · refreshed Aug 6, 2026
Assistance listing 93.399 · Cancer Control
Real awards this federal program has made — the whole assistance listing (93.399), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 0 | — | — |
| FY 2025 | 1 | $2,490,206 | $2,490,206 – $2,490,206 |
| FY 2024 | 13 | $3,165,783 | $804,361 – $3,227,950 |
| FY 2023 | 7 | $1,121,797 | $947,583 – $1,353,065 |
| FY 2022 | 14 | $4,573,965 | $2,523,875 – $6,154,995 |
| FY 2021 | 5 | $3,186,801 | $2,957,140 – $3,199,301 |
- UNIVERSITY OF DELAWARE $16,730,455 · FY 2021
- VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY $8,183,001 · FY 2022
- FRED HUTCHINSON CANCER CENTER $7,696,898 · FY 2022
- THE INSTITUTE FOR CANCER RESEARCH $6,471,989 · FY 2022
- WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $4,655,326 · FY 2022
Source: USASpending.gov · refreshed Aug 22, 2026