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Simpler Grants

No. PAR-25-255 · National Institutes of Health

Open

Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement
Award range
Not specified
Expected awards
Not specified
Application deadline
Nov 5, 2026
Posted
Nov 15, 2024
Last verified
Today

At a glance

AI summary

This program funds new theory, models, and methods to better understand the genetic architecture of complex human traits, including work that integrates genetic and non-genetic factors across biological, social, and ecological scales. It is open to a wide range of applicants, including nonprofits, universities, governments, small businesses, for-profits, and foreign organizations, and foreign components of U.S. organizations are allowed. Awards are made as grants; the number of awards depends on NIH appropriations and meritorious applications, and budgets are not limited overall, though NCI applications are capped at $350,000 in direct costs per year. The project period may be up to 5 years, cost sharing is not required, and clinical trials are not allowed.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Health
  • Research & Discovery
  • Researchers & Scholars
  • Biomedical & Disease Research
Official description from grants.gov

The goal of this NOFO is to support applications for novel theory and methods development that enable better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary drawing from the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, modeling, and validation with available large-scale datasets.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide

Program history

USASpending.gov

Assistance listing 93.172 · Human Genome Research

Real awards this federal program has made — the whole assistance listing (93.172), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 59 $719,909 $248,971 – $2,040,991
FY 2025 100 $491,802 $283,764 – $1,360,276
FY 2024 180 $737,013 $395,019 – $1,360,662
FY 2023 179 $766,801 $392,035 – $2,341,997
FY 2022 175 $894,953 $401,519 – $2,830,080
FY 2021 215 $1,999,233 $431,511 – $5,047,468
Who wins it Higher education (576), Nonprofit (196), Business (100) of 908 awards — categories can overlap.
Top states CA (163) · MA (125) · NY (103) · PA (43) · NC (17)
Largest recent awards
  1. BAYLOR COLLEGE OF MEDICINE $26,395,336 · FY 2021
  2. UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $24,964,130 · FY 2021
  3. THE LELAND STANFORD JUNIOR UNIVERSITY $22,977,417 · FY 2021
  4. THE BROAD INSTITUTE, INC $22,339,977 · FY 2021
  5. JACKSON LABORATORY $21,311,202 · FY 2021

Source: USASpending.gov · refreshed Aug 16, 2026

Assistance listing 93.242 · Mental Health Research Grants

Real awards this federal program has made — the whole assistance listing (93.242), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 491 $451,000 $167,702 – $811,948
FY 2025 600 $731,738 $320,544 – $1,460,736
FY 2024 883
FY 2023 898
FY 2022 986
FY 2021 945

Dollar figures are based on the 1,000 most recent awards we store, not all 4,803 — award counts are complete.

Who wins it Higher education (3,532), Nonprofit (816), Business (215) of 4,803 awards — categories can overlap.
Top states CA (166) · NY (127) · MA (104) · PA (79) · IL (22)
Largest recent awards
  1. MASSACHUSETTS INSTITUTE OF TECHNOLOGY $21,714,815 · FY 2025
  2. OHIO STATE UNIVERSITY, THE $19,515,757 · FY 2025
  3. ALBERT EINSTEIN COLLEGE OF MEDICINE $18,270,924 · FY 2025
  4. DUKE UNIVERSITY $15,039,330 · FY 2025
  5. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI $12,007,972 · FY 2026

Source: USASpending.gov · refreshed Aug 6, 2026

Assistance listing 93.399 · Cancer Control

Real awards this federal program has made — the whole assistance listing (93.399), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 0
FY 2025 1 $2,490,206 $2,490,206 – $2,490,206
FY 2024 13 $3,165,783 $804,361 – $3,227,950
FY 2023 7 $1,121,797 $947,583 – $1,353,065
FY 2022 14 $4,573,965 $2,523,875 – $6,154,995
FY 2021 5 $3,186,801 $2,957,140 – $3,199,301
Who wins it Higher education (28), Nonprofit (8) of 40 awards — categories can overlap.
Top states CA (5) · WA (5) · MI (3) · NY (3) · GA (2)
Largest recent awards
  1. UNIVERSITY OF DELAWARE $16,730,455 · FY 2021
  2. VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY $8,183,001 · FY 2022
  3. FRED HUTCHINSON CANCER CENTER $7,696,898 · FY 2022
  4. THE INSTITUTE FOR CANCER RESEARCH $6,471,989 · FY 2022
  5. WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $4,655,326 · FY 2022

Source: USASpending.gov · refreshed Aug 22, 2026