No. PAR-25-122 · National Institutes of Health
Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement
- Award range
- Up to $100,000
- Expected awards
- Not specified
- Application deadline
- Nov 16, 2027
- Posted
- Oct 28, 2024
- Last verified
- Yesterday
At a glance
AI summaryThis program funds small one-year pilot or feasibility projects that generate preliminary data and tools to study understudied proteins linked to rare diseases. It is open to a wide range of U.S. and foreign-eligible organizations, including nonprofits, universities, governments, small businesses, and tribal organizations, but foreign organizations and non-domestic components of U.S. organizations are not eligible. Awards are limited to $100,000 in direct costs for one year, and the number of awards depends on NIH appropriations and the number of meritorious applications. No cost sharing is required. Applications must focus on one or more of the listed eligible proteins and a rare disease, and clinical trials, clinical drug development studies, and applications not focused on rare diseases will not be reviewed.
AI-generated summary — verify against the announcement
What it funds
Official description from grants.gov
The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to elucidate a role for understudied proteins in rare disease. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s). A list of eligible proteins is provided and are members of druggable protein families that have a known association with a rare disease. This NOFO is intended to jumpstart research on understudied proteins that are associated with rare diseases and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins within the context of rare disease.
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments
Program history
USASpending.govAssistance listing 93.121 · Oral Diseases and Disorders Research
Real awards this federal program has made — the whole assistance listing (93.121), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 155 | $429,000 | $306,500 – $571,863 |
| FY 2025 | 277 | $429,000 | $310,295 – $829,259 |
| FY 2024 | 301 | $491,193 | $310,985 – $1,283,003 |
| FY 2023 | 320 | $444,000 | $298,673 – $1,756,575 |
| FY 2022 | 295 | — | — |
| FY 2021 | 305 | — | — |
For comparison, this notice advertises Up to $100,000.
Dollar figures are based on the 1,000 most recent awards we store, not all 1,653 — award counts are complete.
- TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE $6,128,166 · FY 2023
- THE GENERAL HOSPITAL CORPORATION $4,961,133 · FY 2023
- RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK $4,002,156 · FY 2023
- DANA-FARBER CANCER INSTITUTE, INC. $3,742,682 · FY 2025
- TRUSTEES OF INDIANA UNIVERSITY $3,736,064 · FY 2023
Source: USASpending.gov · refreshed Aug 16, 2026
Assistance listing 93.173 · Research Related to Deafness and Communication Disorders
Real awards this federal program has made — the whole assistance listing (93.173), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 170 | $416,419 | $134,042 – $648,731 |
| FY 2025 | 238 | $418,797 | $187,647 – $1,008,401 |
| FY 2024 | 283 | $464,268 | $152,978 – $1,268,772 |
| FY 2023 | 260 | $689,002 | $272,758 – $1,868,608 |
| FY 2022 | 286 | $570,000 | $145,264 – $2,113,099 |
| FY 2021 | 246 | — | — |
For comparison, this notice advertises Up to $100,000.
Dollar figures are based on the 1,000 most recent awards we store, not all 1,483 — award counts are complete.
- REGENTS OF THE UNIVERSITY OF MINNESOTA $4,621,171 · FY 2022
- UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES $4,589,310 · FY 2023
- THE JOHNS HOPKINS UNIVERSITY $4,474,844 · FY 2022
- OREGON HEALTH & SCIENCE UNIVERSITY $3,863,432 · FY 2022
- THE LELAND STANFORD JUNIOR UNIVERSITY $3,579,023 · FY 2022
Source: USASpending.gov · refreshed Aug 16, 2026
Assistance listing 93.242 · Mental Health Research Grants
Real awards this federal program has made — the whole assistance listing (93.242), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 491 | $451,000 | $167,702 – $811,948 |
| FY 2025 | 600 | $731,738 | $320,544 – $1,460,736 |
| FY 2024 | 883 | — | — |
| FY 2023 | 898 | — | — |
| FY 2022 | 986 | — | — |
| FY 2021 | 945 | — | — |
For comparison, this notice advertises Up to $100,000.
Dollar figures are based on the 1,000 most recent awards we store, not all 4,803 — award counts are complete.
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY $21,714,815 · FY 2025
- OHIO STATE UNIVERSITY, THE $19,515,757 · FY 2025
- ALBERT EINSTEIN COLLEGE OF MEDICINE $18,270,924 · FY 2025
- DUKE UNIVERSITY $15,039,330 · FY 2025
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI $12,007,972 · FY 2026
Source: USASpending.gov · refreshed Aug 6, 2026
Assistance listing 93.350 · National Center for Advancing Translational Sciences
Real awards this federal program has made — the whole assistance listing (93.350), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 106 | $427,386 | $166,500 – $755,137 |
| FY 2025 | 110 | $427,602 | $178,000 – $1,833,042 |
| FY 2024 | 137 | $463,150 | $176,720 – $2,139,478 |
| FY 2023 | 131 | $363,189 | $155,500 – $3,024,000 |
| FY 2022 | 106 | $438,741 | $156,117 – $1,906,971 |
| FY 2021 | 76 | $324,197 | $28,713 – $1,276,814 |
For comparison, this notice advertises Up to $100,000.
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI $46,369,962 · FY 2022
- TRUSTEES OF TUFTS COLLEGE $44,451,810 · FY 2023
- PRESIDENT AND FELLOWS OF HARVARD COLLEGE $43,319,327 · FY 2023
- REGENTS OF THE UNIVERSITY OF MICHIGAN $39,816,036 · FY 2023
- THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER $39,349,638 · FY 2021
Source: USASpending.gov · refreshed Aug 30, 2026
Assistance listing 93.853 · Extramural Research Programs in the Neurosciences and Neurological Disorders
Real awards this federal program has made — the whole assistance listing (93.853), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 654 | $405,461 | $120,825 – $587,738 |
| FY 2025 | 923 | $491,085 | $157,949 – $1,077,840 |
| FY 2024 | 1,031 | — | — |
| FY 2023 | 1,194 | — | — |
| FY 2022 | 1,228 | — | — |
| FY 2021 | 1,132 | — | — |
For comparison, this notice advertises Up to $100,000.
Dollar figures are based on the 1,000 most recent awards we store, not all 6,162 — award counts are complete.
- THE LELAND STANFORD JUNIOR UNIVERSITY $5,747,701 · FY 2025
- YALE UNIV $4,888,497 · FY 2025
- MAYO CLINIC $3,746,535 · FY 2026
- REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE $3,153,019 · FY 2025
- UNIVERSITY OF CALIFORNIA, LOS ANGELES $3,109,857 · FY 2025
Source: USASpending.gov · refreshed Aug 23, 2026
Assistance listing 93.855 · Allergy and Infectious Diseases Research
Real awards this federal program has made — the whole assistance listing (93.855), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 1,817 | $295,722 | $146,402 – $737,210 |
| FY 2025 | 1,596 | — | — |
| FY 2024 | 1,720 | — | — |
| FY 2023 | 1,711 | — | — |
| FY 2022 | 1,576 | — | — |
| FY 2021 | 1,857 | — | — |
For comparison, this notice advertises Up to $100,000.
Dollar figures are based on the 1,000 most recent awards we store, not all 10,277 — award counts are complete.
- SCRIPPS RESEARCH INSTITUTE $3,679,976 · FY 2026
- REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE $3,499,366 · FY 2026
- UNIVERSITY OF WASHINGTON $3,414,775 · FY 2026
- UNIVERSITY OF FLORIDA $3,389,992 · FY 2026
- ALBERT EINSTEIN COLLEGE OF MEDICINE $3,204,071 · FY 2026
Source: USASpending.gov · refreshed Aug 23, 2026