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Simpler Grants

No. PAR-25-052 · National Institutes of Health

Open

NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)

grants.gov listing Full announcement (NOFO)
Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement.” — From the announcement
Award range
Not specified
Expected awards
Not specified
Application deadline
Nov 19, 2026
Posted
Nov 20, 2024
Last verified
Yesterday

At a glance

AI summary

This program funds multi-center stroke clinical trials, biomarker and outcome-validation studies, and ancillary studies related to stroke prevention, treatment, and recovery. It is for a wide range of applicants, including higher education institutions, nonprofits, for-profit organizations, governments, tribal governments, federal agencies, and other eligible entities. The award uses a UG3/UH3 cooperative agreement with a start-up phase of up to 1 year and an execution phase of up to 6 years, and the number of awards depends on NIH appropriations and meritorious applications. Award budgets are not limited, there is no cost-share requirement stated, and studies are generally expected to use the NIH StrokeNet network in the United States, with some non-U.S. sites or ad hoc sites allowed in limited cases.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Research & Discovery
  • Patients & People with Health Conditions
  • Researchers & Scholars
  • Biomedical & Disease Research
Official description from grants.gov

This NOFO encourages applications for multi-site exploratory and confirmatory clinical trials focused on promising interventions; biomarker or outcome measure validation studies that are immediately preparatory to trials in stroke prevention, treatment, and recovery; and ancillary studies designed to add scientific aims to active studies being conducted within StrokeNet. Successful applicants will collaborate and conduct the study within the NIH StrokeNet. Following peer review, NINDS will prioritize studies among the highest scoring to be conducted in the NIH StrokeNet infrastructure. The NIH StrokeNet National Coordinating Center (NCC) will work with the successful applicant to implement the proposed study efficiently and the National Data Management Center (NDMC) will provide statistical and data management support. The NIH StrokeNet Regional Coordinating Centers (RCCs) and their affiliated clinical sites will provide recruitment/retention support as well as on-site implementation of the clinical protocol.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide

Program history

USASpending.gov

Assistance listing 93.853 · Extramural Research Programs in the Neurosciences and Neurological Disorders

Real awards this federal program has made — the whole assistance listing (93.853), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 654 $405,461 $120,825 – $587,738
FY 2025 923 $491,085 $157,949 – $1,077,840
FY 2024 1,031 — —
FY 2023 1,194 — —
FY 2022 1,228 — —
FY 2021 1,132 — —

Dollar figures are based on the 1,000 most recent awards we store, not all 6,162 — award counts are complete.

Who wins it Higher education (4,669), Nonprofit (990), Business (259) of 6,162 awards — categories can overlap.
Top states CA (153) · NY (99) · MA (93) · PA (74) · TX (39)
Largest recent awards
  1. THE LELAND STANFORD JUNIOR UNIVERSITY $5,747,701 · FY 2025
  2. YALE UNIV $4,888,497 · FY 2025
  3. MAYO CLINIC $3,746,535 · FY 2026
  4. REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE $3,153,019 · FY 2025
  5. UNIVERSITY OF CALIFORNIA, LOS ANGELES $3,109,857 · FY 2025

Source: USASpending.gov · refreshed Aug 23, 2026