No. PAR-24-306 · National Institutes of Health
Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
- Award range
- Up to $499,000
- Expected awards
- Not specified
- Application deadline
- Sep 7, 2026 5 days left
- Posted
- Nov 6, 2024
- Last verified
- Today
At a glance
AI summaryThis NIH/NCI grant supports projects that improve, expand, or transform the use of mammalian cancer and tumor models for translational research, including organoids, tumoroids, and cell models. It is open to a wide range of applicants, including nonprofits, universities, for-profit organizations, governments, tribal entities, and foreign organizations, and foreign components are allowed. Awards are limited to $499,000 in direct costs per year, for up to 5 years, and the number of awards depends on NIH appropriations and the quality of applications. No cost sharing is required, and applications proposing clinical trials, mechanistic non-clinical cancer research, or development of new models for non-clinical research are not responsive.
AI-generated summary — verify against the announcement
What it funds
Official description from grants.gov
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research. With this NOFO, the NCI intends to encourage submission of projects devoted to demonstrating that mammalian models or their derivatives used for translational research are robust representations of human biology, are appropriate to test questions of clinical importance, and provide reliable information for patients' benefit. These practical goals contrast with the goals of many mechanistic, NCI-supported R01 projects that employ mammals, or develop and use mammalian cancer models, transplantation tumor models, or models derived from mammalian or human tissues or cells for hypothesis-testing, non-clinical research. Among many other possible endeavors, applicants in response to this FOA could propose demonstrations of how to overcome translational deficiencies of mammalian oncology models, define new uses of mammalian models or their genetics for unexplored translational challenges, advance standard practices for use of translational models, test approaches to validate and credential models, or challenge current practices for how models are used translationally
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments
Program history
USASpending.govAssistance listing 93.393 · Cancer Cause and Prevention Research
Real awards this federal program has made — the whole assistance listing (93.393), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 167 | $596,996 | $422,899 – $685,984 |
| FY 2025 | 233 | $743,438 | $397,772 – $1,287,560 |
| FY 2024 | 331 | $1,232,605 | $403,858 – $1,928,145 |
| FY 2023 | 333 | $1,580,141 | $399,888 – $2,324,497 |
| FY 2022 | 371 | — | — |
| FY 2021 | 317 | — | — |
For comparison, this notice advertises Up to $499,000.
Dollar figures are based on the 1,000 most recent awards we store, not all 1,752 — award counts are complete.
- HEALTH RESEARCH, INC. $8,975,418 · FY 2023
- REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE $7,529,016 · FY 2024
- WAKE FOREST UNIVERSITY HEALTH SCIENCES $7,411,948 · FY 2023
- VANDERBILT UNIVERSITY MEDICAL CENTER $7,120,874 · FY 2023
- REGENTS OF THE UNIVERSITY OF MINNESOTA $6,827,635 · FY 2023
Source: USASpending.gov · refreshed Aug 14, 2026
Assistance listing 93.394 · Cancer Detection and Diagnosis Research
Real awards this federal program has made — the whole assistance listing (93.394), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 137 | $595,012 | $414,585 – $662,610 |
| FY 2025 | 184 | $726,875 | $399,923 – $1,297,708 |
| FY 2024 | 215 | $1,129,641 | $414,953 – $1,862,878 |
| FY 2023 | 268 | $1,754,736 | $438,924 – $2,398,100 |
| FY 2022 | 277 | $2,036,627 | $596,368 – $3,077,027 |
| FY 2021 | 269 | — | — |
For comparison, this notice advertises Up to $499,000.
Dollar figures are based on the 1,000 most recent awards we store, not all 1,350 — award counts are complete.
- TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE $8,347,015 · FY 2022
- BATTELLE MEMORIAL INSTITUTE $6,630,183 · FY 2022
- THE JOHNS HOPKINS UNIVERSITY $6,618,085 · FY 2022
- SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH $6,181,895 · FY 2022
- OREGON HEALTH & SCIENCE UNIVERSITY $5,771,926 · FY 2022
Source: USASpending.gov · refreshed Aug 14, 2026
Assistance listing 93.395 · Cancer Treatment Research
Real awards this federal program has made — the whole assistance listing (93.395), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 316 | $565,152 | $413,691 – $664,926 |
| FY 2025 | 435 | $677,787 | $402,400 – $1,233,798 |
| FY 2024 | 488 | $1,140,586 | $408,966 – $1,897,871 |
| FY 2023 | 522 | — | — |
| FY 2022 | 519 | — | — |
| FY 2021 | 517 | — | — |
For comparison, this notice advertises Up to $499,000.
Dollar figures are based on the 1,000 most recent awards we store, not all 2,797 — award counts are complete.
- THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER $6,902,371 · FY 2024
- VIRGINIA COMMONWEALTH UNIVERSITY $5,325,147 · FY 2024
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY $4,597,865 · FY 2024
- PRIVO TECHNOLOGIES, INC. $4,499,992 · FY 2024
- FRED HUTCHINSON CANCER CENTER $4,234,248 · FY 2025
Source: USASpending.gov · refreshed Aug 18, 2026
Assistance listing 93.396 · Cancer Biology Research
Real awards this federal program has made — the whole assistance listing (93.396), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 289 | $565,909 | $400,614 – $660,808 |
| FY 2025 | 261 | $975,084 | $432,098 – $1,309,674 |
| FY 2024 | 333 | $1,287,771 | $456,103 – $1,958,901 |
| FY 2023 | 383 | $1,541,433 | $747,000 – $2,025,032 |
| FY 2022 | 401 | — | — |
| FY 2021 | 396 | — | — |
For comparison, this notice advertises Up to $499,000.
Dollar figures are based on the 1,000 most recent awards we store, not all 2,063 — award counts are complete.
- RUTGERS, THE STATE UNIVERSITY $11,640,000 · FY 2024
- TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE $7,902,036 · FY 2023
- SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE $6,972,263 · FY 2024
- THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $5,522,226 · FY 2024
- WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $5,035,979 · FY 2024
Source: USASpending.gov · refreshed Aug 22, 2026