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Simpler Grants

No. PAR-25-256 · National Institutes of Health

Open

Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)

Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement
Award range
Not specified
Expected awards
Not specified
Application deadline
Jan 7, 2027
Posted
Nov 15, 2024
Last verified
3 days ago

At a glance

AI summary

This NIH funding opportunity supports new theory, models, and methods for understanding the genetic architecture of complex human traits. It is open to a wide range of U.S. and non-U.S. organizations, including nonprofits, universities, governments, for-profit firms, and foreign organizations, and foreign components of U.S. organizations are allowed. Awards are limited to a two-year project period, with up to $275,000 in direct costs total and no more than $200,000 in any single year. No cost sharing is required. The announcement is not for clinical trials, and new data generation for validation cannot exceed 20% of direct costs; existing data used must be publicly available.

AI-generated summary — verify against the announcement

What it funds

  • Education
  • Health
  • Research & Discovery
  • Researchers & Scholars
  • Biomedical & Disease Research
Official description from grants.gov

The goal of this NOFO is to support R21 applications for novel theory and methods development that better delineate how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary across the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, simulations, and validation using available large-scale datasets

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide

Program history

USASpending.gov

Assistance listing 93.172 · Human Genome Research

Real awards this federal program has made — the whole assistance listing (93.172), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 59 $719,909 $248,971 – $2,040,991
FY 2025 100 $491,802 $283,764 – $1,360,276
FY 2024 180 $737,013 $395,019 – $1,360,662
FY 2023 179 $766,801 $392,035 – $2,341,997
FY 2022 175 $894,953 $401,519 – $2,830,080
FY 2021 215 $1,999,233 $431,511 – $5,047,468
Who wins it Higher education (576), Nonprofit (196), Business (100) of 908 awards — categories can overlap.
Top states CA (163) · MA (125) · NY (103) · PA (43) · NC (17)
Largest recent awards
  1. BAYLOR COLLEGE OF MEDICINE $26,395,336 · FY 2021
  2. UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL $24,964,130 · FY 2021
  3. THE LELAND STANFORD JUNIOR UNIVERSITY $22,977,417 · FY 2021
  4. THE BROAD INSTITUTE, INC $22,339,977 · FY 2021
  5. JACKSON LABORATORY $21,311,202 · FY 2021

Source: USASpending.gov · refreshed Aug 16, 2026

Assistance listing 93.399 · Cancer Control

Real awards this federal program has made — the whole assistance listing (93.399), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 0
FY 2025 1 $2,490,206 $2,490,206 – $2,490,206
FY 2024 13 $3,165,783 $804,361 – $3,227,950
FY 2023 7 $1,121,797 $947,583 – $1,353,065
FY 2022 14 $4,573,965 $2,523,875 – $6,154,995
FY 2021 5 $3,186,801 $2,957,140 – $3,199,301
Who wins it Higher education (28), Nonprofit (8) of 40 awards — categories can overlap.
Top states CA (5) · WA (5) · MI (3) · NY (3) · GA (2)
Largest recent awards
  1. UNIVERSITY OF DELAWARE $16,730,455 · FY 2021
  2. VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY $8,183,001 · FY 2022
  3. FRED HUTCHINSON CANCER CENTER $7,696,898 · FY 2022
  4. THE INSTITUTE FOR CANCER RESEARCH $6,471,989 · FY 2022
  5. WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY $4,655,326 · FY 2022

Source: USASpending.gov · refreshed Aug 22, 2026