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Simpler Grants

No. PAR-25-156 · National Institutes of Health

Open

Limited Competition: High Impact Specialized Innovation Programs in Clinical and Translational Science (RC2 Clinical Trials Optional)

grants.gov listing Full announcement (NOFO)
Dealbreakers No cost share required Audit: not stated
Not reimbursement-only
“Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement
Invitation only
“This limited competition Notice of Funding Opportunity (NOFO) seeks to support novel approaches” — From the announcement
Award range
Not specified
Expected awards
Not specified
Application deadline
Sep 28, 2026 26 days left
Posted
Dec 10, 2024
Last verified
Today

At a glance

AI summary

This program funds high-impact, specialized innovation projects at CTSA UM1 hubs that create new resources, tools, technologies, methods, or discovery-based science to advance clinical and translational science. Only the primary UM1 hub organization can apply, and applications may come from an active CTSA UM1 hub; foreign organizations and non-domestic components of U.S. organizations are not eligible. Award budgets are limited to no more than $500,000 per year in direct costs, excluding consortium or contractual F&A costs, and the project period may be up to 5 years. Cost sharing is not required. A hub may submit up to two RC2 applications per cycle and may have up to two RC2 awards at a time; the RC2 is awarded only if the applicant organization has an awarded UM1.

AI-generated summary — verify against the announcement

What it funds

  • Health
  • Infrastructure, Construction & Shared Facilities
  • Researchers & Scholars
  • Health Care Delivery, Access & Workforce
  • Research Infrastructure, Instrumentation & Data
Official description from grants.gov

The purpose of the High Impact Specialized Innovation Programs (SIPs) is to support the development and demonstration of unique hub capabilities, research platforms and/or resources to address in a timely manner critical gap areas and/or roadblocks in clinical and translational science at awarded UM1 Clinical and Translational Science Awards (CTSA) Program Hubs (PAR-24-272). Successful programs supported through this funding opportunity are expected to lay a strong foundation for future adoption and/or dissemination of capabilities to additional CTSA Program Hubs.

Who can apply

  • Public and State controlled institutions of higher education
Geographic restriction None found in the announcement — likely nationwide

Program history

USASpending.gov

Assistance listing 93.350 · National Center for Advancing Translational Sciences

Real awards this federal program has made — the whole assistance listing (93.350), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 106 $427,386 $166,500 – $755,137
FY 2025 110 $427,602 $178,000 – $1,833,042
FY 2024 137 $463,150 $176,720 – $2,139,478
FY 2023 131 $363,189 $155,500 – $3,024,000
FY 2022 106 $438,741 $156,117 – $1,906,971
FY 2021 76 $324,197 $28,713 – $1,276,814
Who wins it Higher education (344), Business (161), Nonprofit (137) of 666 awards — categories can overlap.
Top states CA (74) · NY (48) · NC (38) · MA (36) · PA (28)
Largest recent awards
  1. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI $46,369,962 · FY 2022
  2. TRUSTEES OF TUFTS COLLEGE $44,451,810 · FY 2023
  3. PRESIDENT AND FELLOWS OF HARVARD COLLEGE $43,319,327 · FY 2023
  4. REGENTS OF THE UNIVERSITY OF MICHIGAN $39,816,036 · FY 2023
  5. THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER $39,349,638 · FY 2021

Source: USASpending.gov · refreshed Aug 30, 2026