No. RFA-NS-27-007 · National Institutes of Health
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
- Award range
- Not specified
- Expected awards
- ~3
- Application deadline
- Feb 20, 2029
- Posted
- Jun 16, 2026
- Last verified
- 5 days ago
At a glance
No plain-language summary yet for this grant — the official description below is the best source.
What it funds
Official description from grants.gov
The purpose of this Notice of Funding Opportunity (NOFO) is to support the preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics for the treatment of pain. The goal of the program is to accelerate the advancement of promising early-stage therapeutic candidates and facilitate their readiness for Phase II clinical trials. Applicants must have a promising small molecule or biologic lead candidate for optimization, a strong biological rationale for the proposed approach, and established assays to guide the optimization process. The scope of the program includes lead optimization, early-stage development activities, IND-enabling studies, development of pharmacodynamic and/or target engagement biomarkers, preparation and submission of an Investigational New Drug (IND) application, and Phase I clinical testing. This is a milestone-driven, phased cooperative agreement program that involves active participation by NIH program staff in project planning and ongoing monitoring of research progress.
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments
Program history
USASpending.govAssistance listing 93.213 · Research and Training in Complementary and Integrative Health
Real awards this federal program has made — the whole assistance listing (93.213), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 58 | $441,813 | $190,230 – $676,906 |
| FY 2025 | 51 | $472,500 | $321,065 – $1,329,943 |
| FY 2024 | 100 | $562,397 | $286,558 – $1,285,052 |
| FY 2023 | 92 | $695,557 | $380,313 – $1,709,004 |
| FY 2022 | 94 | $715,153 | $419,983 – $1,985,928 |
| FY 2021 | 92 | $1,686,420 | $625,217 – $3,082,386 |
- REGENTS OF THE UNIVERSITY OF MINNESOTA $21,646,919 · FY 2022
- UNIVERSITY OF FLORIDA $11,192,369 · FY 2022
- DUKE UNIVERSITY $7,025,837 · FY 2022
- THE RAND CORPORATION $6,237,409 · FY 2023
- THE SPAULDING REHABILITATION HOSPITAL CORPORATION $5,991,655 · FY 2023
Source: USASpending.gov · refreshed Aug 21, 2026
Assistance listing 93.233 · National Center on Sleep Disorders Research
Real awards this federal program has made — the whole assistance listing (93.233), not just this notice.
No grants-family awards recorded for this program since FY 2021 — it may be new, renamed, or not yet reported to USASpending.
Source: USASpending.gov · refreshed Aug 22, 2026
Assistance listing 93.273 · Alcohol Research Programs
Real awards this federal program has made — the whole assistance listing (93.273), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 100 | $308,491 | $157,932 – $601,291 |
| FY 2025 | 175 | $440,566 | $194,934 – $1,114,948 |
| FY 2024 | 237 | $420,927 | $153,632 – $1,110,810 |
| FY 2023 | 327 | $619,032 | $350,328 – $1,806,361 |
| FY 2022 | 314 | $897,120 | $369,477 – $2,547,224 |
| FY 2021 | 274 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 1,427 — award counts are complete.
- THE JOHNS HOPKINS UNIVERSITY $36,249,682 · FY 2022
- THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $9,079,530 · FY 2022
- BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA $6,335,676 · FY 2023
- VANDERBILT UNIVERSITY $5,361,769 · FY 2024
- LOHOCLA RESEARCH CORP $5,128,513 · FY 2022
Source: USASpending.gov · refreshed Aug 6, 2026
Assistance listing 93.279 · Drug Use and Addiction Research Programs
Real awards this federal program has made — the whole assistance listing (93.279), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 428 | $422,523 | $183,034 – $700,682 |
| FY 2025 | 588 | $709,054 | $348,214 – $1,489,059 |
| FY 2024 | 714 | — | — |
| FY 2023 | 724 | — | — |
| FY 2022 | 740 | — | — |
| FY 2021 | 606 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 3,800 — award counts are complete.
- FLORIDA INTERNATIONAL UNIVERSITY $7,372,834 · FY 2025
- BETH ISRAEL DEACONESS MEDICAL CENTER, INC. $7,081,684 · FY 2025
- UNIVERSITY OF WASHINGTON $7,003,822 · FY 2025
- REACX PHARMACEUTICALS, INC. $6,900,000 · FY 2025
- WORCESTER POLYTECHNIC INSTITUTE $6,889,914 · FY 2025
Source: USASpending.gov · refreshed Aug 18, 2026
Assistance listing 93.395 · Cancer Treatment Research
Real awards this federal program has made — the whole assistance listing (93.395), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 316 | $565,152 | $413,691 – $664,926 |
| FY 2025 | 435 | $677,787 | $402,400 – $1,233,798 |
| FY 2024 | 488 | $1,140,586 | $408,966 – $1,897,871 |
| FY 2023 | 522 | — | — |
| FY 2022 | 519 | — | — |
| FY 2021 | 517 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 2,797 — award counts are complete.
- THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER $6,902,371 · FY 2024
- VIRGINIA COMMONWEALTH UNIVERSITY $5,325,147 · FY 2024
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY $4,597,865 · FY 2024
- PRIVO TECHNOLOGIES, INC. $4,499,992 · FY 2024
- FRED HUTCHINSON CANCER CENTER $4,234,248 · FY 2025
Source: USASpending.gov · refreshed Aug 18, 2026
Assistance listing 93.837 · Cardiovascular Diseases Research
Real awards this federal program has made — the whole assistance listing (93.837), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 910 | $406,108 | $121,423 – $769,962 |
| FY 2025 | 1,358 | $638,002 | $257,444 – $1,262,955 |
| FY 2024 | 1,513 | — | — |
| FY 2023 | 1,478 | — | — |
| FY 2022 | 1,536 | — | — |
| FY 2021 | 1,389 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 8,184 — award counts are complete.
- CHILDRENS HOSPITAL MEDICAL CENTER $6,452,040 · FY 2026
- KAISER FOUNDATION HOSPITALS $3,918,561 · FY 2025
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI $3,605,083 · FY 2026
- UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION $3,229,552 · FY 2026
- NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. $3,002,716 · FY 2026
Source: USASpending.gov · refreshed Aug 22, 2026
Assistance listing 93.838 · Lung Diseases Research
Real awards this federal program has made — the whole assistance listing (93.838), not just this notice.
No grants-family awards recorded for this program since FY 2021 — it may be new, renamed, or not yet reported to USASpending.
Source: USASpending.gov · refreshed Aug 23, 2026
Assistance listing 93.839 · Blood Diseases and Resources Research
Real awards this federal program has made — the whole assistance listing (93.839), not just this notice.
No grants-family awards recorded for this program since FY 2021 — it may be new, renamed, or not yet reported to USASpending.
Source: USASpending.gov · refreshed Aug 23, 2026
Assistance listing 93.840 · Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
Real awards this federal program has made — the whole assistance listing (93.840), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 0 | — | — |
| FY 2025 | 0 | — | — |
| FY 2024 | 1 | $1,998,060 | $1,998,060 – $1,998,060 |
| FY 2023 | 8 | $718,015 | $520,326 – $1,181,909 |
| FY 2022 | 0 | — | — |
| FY 2021 | 0 | — | — |
- MICHIGAN PUBLIC HEALTH INSTITUTE $1,332,220 · FY 2023
- INDIANA DEPARTMENT OF HEALTH $1,304,518 · FY 2023
- MINNESOTA DEPARTMENT OF HEALTH $1,141,039 · FY 2023
- SOUTHERN NEVADA HEALTH DIST $762,811 · FY 2023
- COUNTY OF CHARLESTON $673,219 · FY 2023
Source: USASpending.gov · refreshed Aug 23, 2026
Assistance listing 93.846 · Arthritis, Musculoskeletal and Skin Diseases Research
Real awards this federal program has made — the whole assistance listing (93.846), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 148 | $377,506 | $124,696 – $576,799 |
| FY 2025 | 274 | $432,326 | $224,620 – $1,053,137 |
| FY 2024 | 357 | $473,099 | $306,518 – $1,364,153 |
| FY 2023 | 400 | $611,188 | $300,000 – $1,870,687 |
| FY 2022 | 420 | — | — |
| FY 2021 | 357 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 1,956 — award counts are complete.
- WAKE FOREST UNIVERSITY $10,449,074 · FY 2023
- THE GENERAL HOSPITAL CORPORATION $5,795,791 · FY 2023
- REGENTS OF THE UNIVERSITY OF MICHIGAN $3,579,362 · FY 2023
- VANDERBILT UNIVERSITY MEDICAL CENTER $3,213,591 · FY 2026
- UNIVERSITY OF ALABAMA AT BIRMINGHAM $3,106,910 · FY 2023
Source: USASpending.gov · refreshed Aug 23, 2026
Assistance listing 93.853 · Extramural Research Programs in the Neurosciences and Neurological Disorders
Real awards this federal program has made — the whole assistance listing (93.853), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 654 | $405,461 | $120,825 – $587,738 |
| FY 2025 | 923 | $491,085 | $157,949 – $1,077,840 |
| FY 2024 | 1,031 | — | — |
| FY 2023 | 1,194 | — | — |
| FY 2022 | 1,228 | — | — |
| FY 2021 | 1,132 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 6,162 — award counts are complete.
- THE LELAND STANFORD JUNIOR UNIVERSITY $5,747,701 · FY 2025
- YALE UNIV $4,888,497 · FY 2025
- MAYO CLINIC $3,746,535 · FY 2026
- REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE $3,153,019 · FY 2025
- UNIVERSITY OF CALIFORNIA, LOS ANGELES $3,109,857 · FY 2025
Source: USASpending.gov · refreshed Aug 23, 2026
Assistance listing 93.865 · Child Health and Human Development Extramural Research
Real awards this federal program has made — the whole assistance listing (93.865), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 386 | $392,826 | $79,188 – $593,582 |
| FY 2025 | 665 | $452,972 | $178,000 – $1,225,547 |
| FY 2024 | 785 | — | — |
| FY 2023 | 835 | — | — |
| FY 2022 | 799 | — | — |
| FY 2021 | 764 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 4,234 — award counts are complete.
- PRESIDENT AND FELLOWS OF HARVARD COLLEGE $16,115,056 · FY 2025
- UNIVERSITY OF MIAMI $15,385,183 · FY 2025
- UNIVERSITY OF WASHINGTON $6,635,347 · FY 2025
- GEORGE WASHINGTON UNIVERSITY (THE) $5,117,920 · FY 2025
- RESEARCH TRIANGLE INSTITUTE $4,847,747 · FY 2025
Source: USASpending.gov · refreshed Aug 23, 2026
Assistance listing 93.866 · Aging Research
Real awards this federal program has made — the whole assistance listing (93.866), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 795 | $493,972 | $248,999 – $713,195 |
| FY 2025 | 1,033 | $643,089 | $467,538 – $1,733,010 |
| FY 2024 | 1,560 | — | — |
| FY 2023 | 1,539 | — | — |
| FY 2022 | 1,715 | — | — |
| FY 2021 | 1,595 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 8,237 — award counts are complete.
- REGENTS OF THE UNIVERSITY OF MICHIGAN $15,345,206 · FY 2026
- UNIVERSITY OF UTAH $10,793,501 · FY 2025
- THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK $10,223,348 · FY 2026
- SUTTER BAY HOSPITALS $9,466,491 · FY 2025
- TUFTS MEDICAL CENTER PARENT, INC. $8,296,115 · FY 2026
Source: USASpending.gov · refreshed Aug 23, 2026
Assistance listing 93.867 · Vision Research
Real awards this federal program has made — the whole assistance listing (93.867), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 189 | $440,263 | $132,837 – $633,742 |
| FY 2025 | 309 | $464,903 | $260,661 – $1,026,742 |
| FY 2024 | 408 | $630,967 | $342,920 – $1,431,708 |
| FY 2023 | 401 | $771,099 | $422,359 – $1,867,311 |
| FY 2022 | 391 | — | — |
| FY 2021 | 394 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 2,092 — award counts are complete.
- UNIVERSITY OF CALIFORNIA, SAN DIEGO $8,283,963 · FY 2024
- REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE $5,256,090 · FY 2023
- OHIO STATE UNIVERSITY, THE $4,539,043 · FY 2025
- ALLEN INSTITUTE $4,260,011 · FY 2025
- THE GENERAL HOSPITAL CORPORATION $4,026,010 · FY 2024
Source: USASpending.gov · refreshed Aug 23, 2026