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Simpler Grants

No. PAR-27-057 · National Institutes of Health

Open

Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)

grants.gov listing
Dealbreakers No cost share required Audit: not stated Reimbursement-only: not stated
Award range
Up to $500,000
Expected awards
Not specified
Application deadline
Jul 5, 2029
Posted
Jun 4, 2026
Last verified
6 days ago

At a glance

No plain-language summary yet for this grant — the official description below is the best source.

What it funds

  • Health
  • Research & Discovery
  • Patients & People with Health Conditions
  • Biomedical & Disease Research
Official description from grants.gov

This Notice of Funding Opportunity (NOFO) invites applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that individually, sequentially, or in combination trigger human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses also are encouraged.

Who can apply

  • City or township governments
  • County governments
  • For-profit organizations other than small businesses
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized)
  • Nonprofits with 501(c)(3) status (other than higher education)
  • Nonprofits without 501(c)(3) status (other than higher education)
  • Others
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities / Indian housing authorities
  • Small businesses
  • Special district governments
  • State governments
Geographic restriction None found in the announcement — likely nationwide

Program history

USASpending.gov

Assistance listing 93.121 · Oral Diseases and Disorders Research

Real awards this federal program has made — the whole assistance listing (93.121), not just this notice.

Fiscal year Awards Median award Middle half
FY 2026 (so far) 155 $429,000 $306,500 – $571,863
FY 2025 277 $429,000 $310,295 – $829,259
FY 2024 301 $491,193 $310,985 – $1,283,003
FY 2023 320 $444,000 $298,673 – $1,756,575
FY 2022 295 — —
FY 2021 305 — —

For comparison, this notice advertises Up to $500,000.

Dollar figures are based on the 1,000 most recent awards we store, not all 1,653 — award counts are complete.

Who wins it Higher education (1,224), Nonprofit (242), Business (71) of 1,653 awards — categories can overlap.
Top states CA (124) · PA (83) · MA (82) · NY (70) · TX (35)
Largest recent awards
  1. TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE $6,128,166 · FY 2023
  2. THE GENERAL HOSPITAL CORPORATION $4,961,133 · FY 2023
  3. RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK $4,002,156 · FY 2023
  4. DANA-FARBER CANCER INSTITUTE, INC. $3,742,682 · FY 2025
  5. TRUSTEES OF INDIANA UNIVERSITY $3,736,064 · FY 2023

Source: USASpending.gov · refreshed Aug 16, 2026