No. PAR-27-011 · National Institutes of Health
Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
- Award range
- Not specified
- Expected awards
- Not specified
- Application deadline
- Nov 2, 2028
- Posted
- Mar 18, 2026
- Last verified
- 6 days ago
At a glance
No plain-language summary yet for this grant — the official description below is the best source.
What it funds
Official description from grants.gov
This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. These trials may include ones that test different therapeutic, behavioral, dissemination and implementation science clinical trials and/or prevention strategies. Trials for which this NOFO applies must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial (see NOT-OD-15-015). For additional information about the mission, strategic vision, and research priorities of the NHLBI, applicants are encouraged to consult the NHLBI website.This NOFO will utilize a bi-phasic, milestone-driven mechanism of award. The objective of the application is to present the scientific rationale for the clinical trial and a comprehensive scientific and operational plan that describes it. The application should address project management, participant recruitment and retention, performance milestones, scientific conduct of the trial, and dissemination of results. The multiple PD/PI model is strongly encouraged but not required. Applicants are encouraged to include a PD/PI with expertise in biostatistics, clinical trial design, and coordination. The application should also describe its approaches to increase community engagement from conceptual design of the intervention through implementation and sustainability, close gaps in health outcomes within the US population, and increase health for all.
Who can apply
- City or township governments
- County governments
- For-profit organizations other than small businesses
- Independent school districts
- Native American tribal governments (Federally recognized)
- Native American tribal organizations (other than Federally recognized)
- Nonprofits with 501(c)(3) status (other than higher education)
- Nonprofits without 501(c)(3) status (other than higher education)
- Others
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Public housing authorities / Indian housing authorities
- Small businesses
- Special district governments
- State governments
Program history
USASpending.govAssistance listing 93.233 · National Center on Sleep Disorders Research
Real awards this federal program has made — the whole assistance listing (93.233), not just this notice.
No grants-family awards recorded for this program since FY 2021 — it may be new, renamed, or not yet reported to USASpending.
Source: USASpending.gov · refreshed Aug 22, 2026
Assistance listing 93.837 · Cardiovascular Diseases Research
Real awards this federal program has made — the whole assistance listing (93.837), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 910 | $406,108 | $121,423 – $769,962 |
| FY 2025 | 1,358 | $638,002 | $257,444 – $1,262,955 |
| FY 2024 | 1,513 | — | — |
| FY 2023 | 1,478 | — | — |
| FY 2022 | 1,536 | — | — |
| FY 2021 | 1,389 | — | — |
Dollar figures are based on the 1,000 most recent awards we store, not all 8,184 — award counts are complete.
- CHILDRENS HOSPITAL MEDICAL CENTER $6,452,040 · FY 2026
- KAISER FOUNDATION HOSPITALS $3,918,561 · FY 2025
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI $3,605,083 · FY 2026
- UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION $3,229,552 · FY 2026
- NORTHERN CALIFORNIA INSTITUTE FOR RESEARCH AND EDUCATION, INC. $3,002,716 · FY 2026
Source: USASpending.gov · refreshed Aug 22, 2026
Assistance listing 93.838 · Lung Diseases Research
Real awards this federal program has made — the whole assistance listing (93.838), not just this notice.
No grants-family awards recorded for this program since FY 2021 — it may be new, renamed, or not yet reported to USASpending.
Source: USASpending.gov · refreshed Aug 23, 2026
Assistance listing 93.839 · Blood Diseases and Resources Research
Real awards this federal program has made — the whole assistance listing (93.839), not just this notice.
No grants-family awards recorded for this program since FY 2021 — it may be new, renamed, or not yet reported to USASpending.
Source: USASpending.gov · refreshed Aug 23, 2026
Assistance listing 93.840 · Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
Real awards this federal program has made — the whole assistance listing (93.840), not just this notice.
| Fiscal year | Awards | Median award | Middle half |
|---|---|---|---|
| FY 2026 (so far) | 0 | — | — |
| FY 2025 | 0 | — | — |
| FY 2024 | 1 | $1,998,060 | $1,998,060 – $1,998,060 |
| FY 2023 | 8 | $718,015 | $520,326 – $1,181,909 |
| FY 2022 | 0 | — | — |
| FY 2021 | 0 | — | — |
- MICHIGAN PUBLIC HEALTH INSTITUTE $1,332,220 · FY 2023
- INDIANA DEPARTMENT OF HEALTH $1,304,518 · FY 2023
- MINNESOTA DEPARTMENT OF HEALTH $1,141,039 · FY 2023
- SOUTHERN NEVADA HEALTH DIST $762,811 · FY 2023
- COUNTY OF CHARLESTON $673,219 · FY 2023
Source: USASpending.gov · refreshed Aug 23, 2026