Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)

grants.gov listing Full announcement (NOFO)

Dealbreakers No cost share required

No audit required

“Required Registrations Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award.” — From the announcement

Not reimbursement-only

“Funding Instrument Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.” — From the announcement

Award range: Not specified
Expected awards: Not specified
Application deadline: Nov 16, 2027
Posted: Jan 8, 2025
Last verified: 6 days ago

At a glance

AI summary

This program funds pilot and feasibility projects on basic or translational HIV research within the mission of NIDDK, including studies of biological, behavioral, environmental, psychological, and social factors that contribute to HIV pathogenesis and HIV-related comorbidities, coinfections, complications, and reservoirs. Eligible applicants include many U.S. organizations such as nonprofits, universities, governments, tribal organizations, community-based groups, and for-profit organizations, but foreign organizations and non-domestic components of U.S. organizations are not eligible. Awards are limited to a total of $275,000 in direct costs over two years, with no more than $200,000 in any single year. No cost sharing is required, and the NOFO does not accept clinical trial applications.

AI-generated summary — verify against the announcement

What it funds

Food and Nutrition
Health
Research & Discovery
Researchers & Scholars
Biomedical & Disease Research

Official description from grants.gov

This Notice of Funding Opportunity (NOFO) invites applications for innovative basic and translational pilot research projects within the mission of the NIDDK that are aligned with NIH HIV/AIDS research priorities. These priorities were most recently outlined by the NIH Office of AIDS Research (OAR) in NOT-20-018, UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding, scientific priorities. Potential topics could address multiple overarching priorities. These include elucidation of unique pathophysiological mechanisms contributing to HIV comorbidities, coinfections, and complications (CCCs) affecting organs, tissues, and processes within the mission of the NIDDK. Likewise, interrogations into biological mechanisms underlying HIV reservoirs in NIDDK-relevant tissues are important for developing strategies for long-term viral suppression or eradication. Finally, health-impeding social determinants of health may affect CCCs or viral reservoirs within NIDDK's mission through multiple pathways.

Who can apply

City or township governments
County governments
For-profit organizations other than small businesses
Independent school districts
Native American tribal governments (Federally recognized)
Native American tribal organizations (other than Federally recognized)
Nonprofits with 501(c)(3) status (other than higher education)
Nonprofits without 501(c)(3) status (other than higher education)
Others
Private institutions of higher education
Public and State controlled institutions of higher education
Public housing authorities / Indian housing authorities
Small businesses
Special district governments
State governments

Geographic restriction None found in the announcement — likely nationwide

Program history

USASpending.gov

Assistance listing 93.847 · Diabetes, Digestive, and Kidney Diseases Extramural Research

Real awards this federal program has made — the whole assistance listing (93.847), not just this notice.

Fiscal year	Awards	Median award	Middle half
FY 2026 (so far)	616	$537,141	$153,319 – $771,172
FY 2025	659	$730,832	$270,038 – $1,572,806
FY 2024	929	—	—
FY 2023	961	—	—
FY 2022	975	—	—
FY 2021	1,012	—	—

Dollar figures are based on the 1,000 most recent awards we store, not all 5,152 — award counts are complete.

Who wins it Higher education (3,506), Nonprofit (1,046), Business (356) of 5,152 awards — categories can overlap.

Top states CA (137) · NY (98) · MA (84) · PA (74) · TX (64)

Largest recent awards

BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE $6,282,406 · FY 2026
THE LELAND STANFORD JUNIOR UNIVERSITY $5,583,712 · FY 2026
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA $5,180,852 · FY 2026
NORTHWESTERN UNIVERSITY $4,764,127 · FY 2025
UNIVERSITY OF SOUTH FLORIDA $4,640,761 · FY 2026

Source: USASpending.gov · refreshed Aug 23, 2026